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Common oral diseases, hyposalivation and survival post-HSCT, a longitudinal study
Uutela, P., Passweg, J., Halter, J., Gerull, S., Weiger, R., Mauramo, E., Waltimo, T., Mauramo, M.
European journal of haematology. 2019
Abstract
OBJECTIVES Haematopoietic stem cell transplantation (HSCT) recipients are at risk of side effects within the oral cavity. The purpose of this study was to examine progression of common oral diseases and hyposalivation and their associations with survival in allogeneic HSCT recipients. METHODS 269 adult HSCT recipients treated with HSCT between 2008 and 2016 were included in this study. The associations of caries, decayed, missing, filled teeth (DMFT) index, radiological attachment loss and stimulated salivary flow rate with six-month survival and the progression of the oral disorders within two years were examined. RESULTS Forty HSCT recipients (14.8%) deceased within six months post-HSCT. Among the deceased recipients, hyposalivation and caries were more common pre-HSCT than in recipients who survived over six months (P<0.05). HSCT recipients with hyposalivation pre-HSCT had higher risk of death (HR:1.90, 95% CI:1.00-3.60; P=0.044) within six months post-HSCT compared to recipients without hyposalivation. Hyposalivation pre-HSCT was associated with a higher DMFT index score (P<0.05) and a smaller number of teeth (P<0.005) 24 months post-HSCT in comparison to those without hyposalivation. CONCLUSIONS Hyposalivation and caries were associated with a lower rate of survival in HSCT recipients. Additionally, hyposalivation predisposed to deterioration of oral health post-HSCT. This article is protected by copyright. All rights reserved.