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Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial
Kuhlen, M., Bader, P., Sauer, M., Albert, M. H., Gruhn, B., Gungor, T., Kropshofer, G., Lang, P., Lawitschka, A., Metzler, M., et al
British journal of haematology. 2018
Abstract
Osteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin-Frankfurt-Munster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 10.3 years (range 0.5-26). Cumulative incidence of symptomatic ON (sON) was 9% at 5 years (standard deviation 1%), median time from HSCT to diagnosis of sON was 12.4 months (range 1-126). Multivariate analysis identified age at HSCT [10-15 years vs. <10 years: hazard ratio (HR) 3.73, P = 0.009; >15 years vs. <10 years: HR 5.46, P = 0.001], diagnosis of sON prior to HSCT and chronic graft-versus-host disease (yes versus no: HR 2.696, P = 0.015) as significant independent risk factors for the development of sON.