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Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance
Rossi, F., Zucchetti, G., Esposito, M., Berchialla, P., Sciannameo, V., Vassallo, E., Saglio, F., Chamorro Viña, C., Scarrone, S., Vittorini, R., et al
European journal of cancer care. 2022;:e13711
Abstract
OBJECTIVES The aim of this pilot trial is evaluating the preliminary effectiveness of two in-hospital interventions in the maintenance of motor performance in children/adolescents undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives investigated the interventions' feasibility, impact on fatigue and to what degree the subjects' maintained their ankle dorsiflexion range of movement (ROM), functional mobility, muscle strength and flexibility. METHODS This trial included 5- to 18-year-old participants, affected by oncological and non-oncological diseases during hospitalisation for autologous/allogenic HSCT. The subjects were assigned to an exercise group (EG), or a counselling group based on a cluster model based on inpatient timeframe. The EG subjects performed strengthening, stretching and aerobic exercises for 30 min/5 days a week. Both groups followed rehabilitation counselling indications (RCI), 7 days a week. RESULTS Forty-nine participants were enrolled (median age = 12.9 years) (EG n = 36). In both groups the participants maintained their baseline motor performance and ankle ROM, and the children/adolescents and parents reduced their levels of fatigue. However, the interventions were not effective in maintaining strength. CONCLUSION In maintaining the subjects' motor performance, the RCI results are significant because they pave the way for the application in clinical practice contexts where there are poor rehabilitation resources. Clinical Trials registration NCT03842735.
2.
Rehabilitative intervention during and after pediatric hematopoietic stem cell transplantation: An analysis of the existing literature. [Review]
Rossi, F., Coppo, M., Zucchetti, G., Bazzano, D., Ricci, F., Vassallo, E., Nesi, F., Fagioli, F.
Pediatric Blood & Cancer. 2016;63(11):1895-904
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Abstract
Hematopoietic stem cell transplantation is a therapeutic strategy for several oncohematological diseases. It increases survival rates but leads to a high incidence of related effects. The objective of this paper was to examine the existing literature on physical exercise interventions among pediatric HSCT recipients to explore the most often utilized rehabilitative assessment and treatment tools. Studies published from 2002 to April 1, 2015 were selected: 10 studies were included. A previous literary review has shown that rehabilitation programs have a positive impact on quality of life. Our analysis identified some significant outcome variables and shared intervention areas. Copyright © 2016 Wiley Periodicals, Inc.