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Efficacy of haematopoietic stem cell boost as a rescue for poor graft function after haematopoietic stem cell transplantation: A multicentre retrospective study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Gaffet, M., Wiedemann, A., Dalle, J. H., Bilger, K., Forcade, E., Robin, M., Cornillon, J., Labussière-Wallet, H., Ceballos, P., Bulabois, C. E., et al
British journal of haematology. 2023;201(6):1153-1158
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Editor's Choice
Abstract
Haematopoietic stem cell reinjection may be a curative option for poor graft function after haematopoietic stem cell transplantation; however, literature supporting its use remains limited. We conducted a multicentre retrospective study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy, including 55 patients. We demonstrated response rates of nearly 40% and two-year survival of more than 60% in the context of an otherwise deadly complication and we observed that the timing of injection and the degree of cytopenia are strongly associated with outcomes. This study shows the feasibility of the procedure informing on its epidemiology, outcomes and prognostic factors, setting the stage for future guidelines.
PICO Summary
Population
Children and adults with poor graft function following allogeneic transplant, from 12 centres in France (n=55)
Intervention
Haematopoietic stem cell boost injection
Comparison
None
Outcome
Response rate was nearly 40% and two year survival was more than 60%