1.
Results of two protocols for platelet transfusion in patients undergoing abo incompatible hematopoietic stem cell transplantation
Solves, P., Diaz, A., Carretero, C., Gomez, I., Carpio, N., Sanz, G.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2019
2.
Platelet Transfusion Refractoriness in Single-Unit Cord Blood Transplantation for Adults: Risk Factors and Clinical Outcomes
Tanoue, S., Konuma, T., Kato, S., Oiwa-Monna, M., Isobe, M., Jimbo, K., Takahashi, S., Tojo, A.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018
Abstract
Platelet transfusion refractoriness (PTR) is frequently observed after allogeneic hematopoietic cell transplantation (HCT). However, the incidence of and risk factors for PTR, and impact of PTR on transplant outcomes after cord blood transplantation (CBT) have not been fully investigated. We retrospectively analyzed 185 adult patients who received single-unit CBT in our institute. The mean 16-hour corrected count increment (CCI) for the 5,840 platelet transfusions was 3.68x10(9)/l. Among them, 3,196 transfusions (54.7%) were associated with a PTR with 16-hour-CCI <4.5x10(9)/l. Results of multivariate analysis indicated that the following factors were significantly associated with decreased platelet transfusion responses: female sex with pregnancy history, male sex, the presence of HLA class I antibody, lower cord blood total nucleated cell dose, lower cord blood CD34+ cell dose, 3 locus HLA disparities, body temperature ≥38 degrees C, CRP ≥10mg/dl, cytomegalovirus reactivation, use of foscarnet, and use of liposomal amphotericin B. By contrast, GVHD prophylaxis including methotrexate, ABO minor mismatch, use of ganciclovir, and use of linezolid were significantly associated with better platelet transfusion responses. PTR had a significant effect on poor neutrophil and platelet recovery, and overall mortality after CBT. These data suggest that early phase PTR may be predictive of engraftment and mortality after single-unit CBT for adults.