Ruxolitinib Combined with Corticosteroids as First-line Therapy for Acute Graft Versus Host Disease in Haploidentical Peripheral Blood Stem Cell Transplant Patients

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2020
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Abstract
Corticosteroids are used as first-line treatment for acute GVHD. However, they are effective in only about half of patients. This study prospectively evaluated Ruxolitinib combined with 1 mg/kg methylprednisolone in the initial treatment of acute GVHD. A total of 32 patients were enrolled. Acute GVHD involved skin (53.1%), gastrointestinal tract (68.8%) and liver (6.0%). The complete response rate at day 28 was 96.9%. The 1-year and 2-year cumulative incidence rates of chronic GVHD were 9.4% and 13.8%, respectively. The 1- year cumulative incidence of non-relapse mortality was 8.7%. The Kaplan-Meier curve estimated 1-year overall survival after transplantation at 73.4%. This prospective study suggested that patients with acute GVHD showed a high response rate to Ruxolitinib (5 mg daily) combined with 1 mg/kg/day methylprednisolone. The novel regimen spared steroid exposure, alleviated toxicity and resulted in long-term survival.
Study details
Treatment : GvHD Treatment
Condition : GvHD
Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine