Children and adolescents with acute lymphoblastic leukemia (n=432)
Total body irradiation based myeloablative HSCT
A total 172 patients experienced at least one severe infection (SI). Transplantation from matched unrelated donors (MUD) was associated with any type of SI in the pre-engraftment period and with any SI between day +30 and + 100. Bacterial and fungal infections occurred more often in the pre-engraftment phase and viral infections more often before day +30 or between day +30 and + 100 after HSCT from MUD as compared to matched sibling donors. Chronic GvHD was an independent risk factor for any type of SI after day +100.